Effects of a Chlorogenic Acid-Containing Herbal Medicine (LAS^NB) on Colon Cancer

Figure 5

Hematological toxicity and pathology. No hematological toxicity over Grade II (CTCAE 3.0) was observed in the LAS^NB group compared with the control group. Slight interstitial vascular congestion in lung was observed in the LAS^NB group. In addition, no pathological change was found in the kidney and liver in the LAS^NB group. (a) Routine blood test and liver and kidney function test. For liver and kidney functions, the levels of AST, ALT, BUN, and creatinine were 115.18 ± 21.84 U/l (0–80 U/l), 35.28 ± 4.68 U/l (0–77 U/l), 8.59 ± 1.30 mmol/l (2.8–11.9 mmol/l), and 39.90 ± 4.22 μmol/l (10–80 μmol/l) in the LAS^NB group compared to 126.30 ± 23.68 U/l, 33.52 ± 2.62 U/l, 8.39 ± 0.59 mmol/l, and 36.84 ± 3.41 μmol/l in the control group, respectively (). For routine blood tests, the WBC, RBC, PLT, and LYM% were 2.57 ± 1.34 × 10⁹/l (0.8–6.8 × 10⁹/l), 7.58 ± 0.26 × 10¹²/l (6.36–9.42 × 10¹²/l), 1150.80 ± 149.82 × 10⁹/l (450–1590 × 10^9/l), and 74.18 ± 6.32 (55.8%–90.6%) in the LAS^NB group compared to 3.62 ± 2.47 × 10⁹/l, 7.86 ± 0.30 × 10¹²/l, 1293.60 ± 162.00 × 10⁹/l, and 73.68% ± 7.55% in the control group, respectively (). (b) HE staining of the lung, liver, and kidney tissues.

(a)

(b)