Umbelliprenin Increases the M1/M2 Ratio of Macrophage Polarization and Improves the M1 Macrophage Activity in THP-1 Cells Cocultured with AGS Cells
Table 1
UMB effect on the ratio of M1/M2 in cocultured AGS and THP-1 cells.
PMA + UMB
LPS + IFN-γ + UMB
IL4 + IL13 + UMB
Coculture + UMB
Control
M0-AGS cCoculture
39.88 ± 6.81 ( = 0.0009)
20.00 ± 0.53 (ns)
19.93 ± 1.59
M1-AGS coculture
59.97 ± 7.70 ( < 0.0001)
48.34 ± 3.74 ( = 0.0001)
32.82 ± 0.18 ( = 0.0248)
22.57 ± 3.12
M2-AGS coculture
41.47 ± 2.01 ( < 0.0001)
16.09 ± 1.57 ( < 0.0001)
4.883 ± 0.402 ( = 0.0154)
1.65 ± 0.085
All values are the mean ± SD of at least three independent experiments that have been tested in a triplicate. The data analysis was carried out using the ANOVA method.
