Umbelliprenin Increases the M1/M2 Ratio of Macrophage Polarization and Improves the M1 Macrophage Activity in THP-1 Cells Cocultured with AGS Cells

Table 2

Effect of UMB on nitric oxide concentration (μM) in cocultured media.

	PMA + UMB	LPS + IFN-γ + UMB	IL4 + IL13 + UMB	Coculture + UMB	Control
M0-AGS coculture	11.30 ± 1.16 ( = 0.0229)			9.08 ± 0.39 ( = 0.0006)	13.19 ± 0.51
M1-AGS coculture	5.86 ± 0.84 ( = 0.0035)	3.74 ± 0.96 (ns)		8.19 ± 1.02 ( < 0.0001)	2.97 ± 0.58
M2-AGS coculture	4.41 ± 0.84 (ns)		3.19 ± 0.69 (ns)	3.41 ± 0.84 (ns)	3.08 ± 0.51

All values are the mean ± SD of at least three independent experiments that have been tested in a triplicate. The data analysis was carried out using the ANOVA method.