Umbelliprenin Increases the M1/M2 Ratio of Macrophage Polarization and Improves the M1 Macrophage Activity in THP-1 Cells Cocultured with AGS Cells

Table 3

UMB effect on interleukin-10 and interleukin-12 concentration (pg/ml) in cocultured media.

	M1-AGS coculture		M2-AGS coculture
	Coculture + UMB	Control	Coculture + UMB	Control
IL-10	8.77 ± 0.25	13.73 ± 0.12 ( < 0.0001)	16.67 ± 0.29	25.07 ± 0.97 ( = 0.0001)
IL-12	52.99 ± 9.46 ( = 0.0052)	22.29 ± 1.81	34.70 ± 4.90 ( = 0.0067)	59.88 ± 6.88

All values are the mean ± SD of at least three independent experiments that have been tested in a triplicate. An unpaired t-test was used for data analysis.