Research Article
Acute and Subchronic Toxicological Evaluation of the Herbal Product HAD-B1 in Rats
Table 7
Histopathological findings of rats treated with HAD-B1 for 13-week period.
| | Organ | N | Histological findings | Male | Female | | G1 | G4 | G1 | G4 |
| | Liver | 10 | Inflammatory cell foci | | Minimal, multifocal | 2 | 2 | 0 | 1 | | Kidney | 10 | Tubular basophilia | | Minimal, multifocal | 3 | 2 | 0 | 0 | | Minimal, focal | 0 | 1 | 0 | 0 | | Slight, multifocal | 0 | 1 | 0 | 0 | | Tubular casts | | Present | 1 | 0 | 0 | 0 | | Cortical scar | | Present | 1 | 0 | 2 | 0 | | Medullary mineralization | | Minimal, multifocal | 1 | 0 | 2 | 0 | | Adrenal gland | 10 | Cortical vacuolation | | Minimal, diffuse | 2 | 2 | 0 | 0 | | Lung | 10 | Inflammatory cell infiltration, perivascular | | Minimal, multifocal | 2 | 0 | 0 | 0 | | Prostate gland | | Inflammatory cell infiltration, interstitial | | | — | — | | Minimal, multifocal | 2 | 1 | | Slight, multifocal | 0 | 1 | | Concretion | | | | Minimal, multifocal | 1 | 0 | | Testis | 10 | Bilateral tubular atrophy | | | — | — | | Severe, diffuse | 0 | 1∗ | | Epididymis | 10 | Oligospermia, bilateral | | | — | — | | Moderate, diffuse | 0 | 1 | | Thyroid gland | 10 | Ultimobranchial cysts | | | | | | Present | 1 | 0 | 0 | 0 | | Mammary gland | 10 | Adenocarcinoma | — | — | | | | Present | | | 1∗∗ | 0 |
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—: not applicable; : reduced testis at necropsy; : mass on the right mammary gland at necropsy. |
