Research Article
New Therapeutic Insight into the Effect of Ma Huang Tang on Blood Pressure and Renal Dysfunction in the L-NAME-Induced Hypertension
Figure 2
Effect of MHT on vasodilation and cGMP production. Presented vascular relaxation response to MHT in aorta with endothelium or without (a) Presence of L-NAME (100 μM) or wortmannin (0.1 μM) (b). Presence of ODQ (10 μM) (c). The cGMP production response to MHT with L-NAME (100 μM), ODQ (10 μM), or wortmannin (0.1 μM). MHT, Ma Huang Tang; cGMP: guanosine 3′,5′-cyclic monophosphate; L-NAME: NG-nitro-L-arginine methylester; and ODQ: 1H-[1,2,4]-oxadiazolo-[4,3-α]-quinoxalin-1-one. Values are expressed as mean ± S.E. (n = 5 per group). , , and versus vehicle: # versus L-NAME, ODQ, or wortmannin.
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