Research Article
New Therapeutic Insight into the Effect of Ma Huang Tang on Blood Pressure and Renal Dysfunction in the L-NAME-Induced Hypertension
Figure 7
Summary of MHT action in L-NAME-induced hypertensive rats. L-NAME inhibited NO production; therefore, Akt, eNOS, and cGMP activation was decreased. Meanwhile, MHT activated PI3K/Akt/eNOS signaling; as a result, cGMP production was increased. MHT: Ma Huang Tang; eNOS: endothelial nitric oxide synthase; cGMP: guanosine 3′,5′-cyclic monophosphate; and OMT: Olmetec.