Ameliorative Potential of Resveratrol in Dry Eye Disease by Restoring Mitochondrial Function

Figure 4

Resveratrol ameliorates DED syndrome in vivo via SIRT1. (a) The tear production in control mice, DED mice, DED mice treated with alcohol, or DED mice treated with resveratrol measured by the phenol red cotton thread test. (b) Corneal fluorescein staining in control mice, DED mice, DED mice with alcohol treatment, and DED mice treated with resveratrol. (c) Goblet cell density in the conjunctival epithelial layer measured by periodic acid-Schiff (PAS) staining. (d) Expression of SIRT1 in lacrimal glands determined by Western blotting. (e) Expression of GPx and SOD2 in lacrimal glands determined by Western blotting. n = 3. , , .

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