[Retracted] Wild Bitter Melon Extract Abrogates Hypoxia-Induced Cell Death via the Regulation of Ferroptosis, ER Stress, and Apoptosis in Microglial BV2 Cells

Figure 3

WBM-alleviated hypoxia triggers ferroptosis and ER stress in microglial BV-2 cells via Gpx4/SLC7A11 and CHOP/Bip-dependent pathways, respectively. (a) The upper panel indicates expression changes of Gpx4/SLC7A11 proteins. The lower panel indicates the quantitative results of assessing specific proteins using Image J. (b) The upper panel indicates expression changes of CHOP and Bip proteins. The lower panel indicates the quantitative results of assessing specific proteins using Image J. (c) Expression changes of Gpx4 and SLC7A11 proteins in presence or absence of 20 μM erastin. (d) Expression changes of CHOP and Bip proteins in presence or absence of 1 uM thapsigargin (Thg). Three independent replicates were used to calculate the standard deviation (n = 3). . H, hypoxia. H/WBM, in presence of 30 μM WBM under hypoxia.

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