[Retracted] Wild Bitter Melon Extract Abrogates Hypoxia-Induced Cell Death via the Regulation of Ferroptosis, ER Stress, and Apoptosis in Microglial BV2 Cells

<div>The schematic depicts the functional mechanisms of WBM in hypoxia-caused damage in microglial BV-2 cells. (a) Hypoxia increased ferroptosis and apoptosis via regulations of GPX4/SLC7A11 and cleaved-caspase3/Bax/Bcl-2, respectively. Moreover, hypoxia also induced ER stress via the regulation of CHOP/Bip. (b) WBM reversed the hypoxia-triggered ferroptosis and apoptosis via regulations of GPX4/SLC7A11 and cleaved-caspase3/Bax/Bcl-2, respectively. Conversely, WBM also alleviated hypoxia-induced ER stress via the regulation of CHOP/Bip. This figure was created with <a href="https://www.BioRender.com">https://www.BioRender.com</a>.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 5

Figure 5: [Retracted] Wild Bitter Melon Extract Abrogates Hypoxia-Induced Cell Death via the Regulation of Ferroptosis, ER Stress, and Apoptosis in Microglial BV2 Cells 

Figure 5 | [Retracted] Wild Bitter Melon Extract Abrogates Hypoxia-Induced Cell Death via the Regulation of Ferroptosis, ER Stress, and Apoptosis in Microglial BV2 Cells 