Efficacy and Safety of Chuan Huang Fang Combining Reduced Glutathione in Treating Acute Kidney Injury (Grades 1–2) on Chronic Kidney Disease (Stages 2–4): Study Protocol for a Multicenter Randomized Controlled Clinical Trial

Table 1

KDIGO classification of AKI.

Stage	Serum creatinine	Urine output
1	1.5–1.9 times baseline, or ≥0.3 mg/dl (26.5 μmol/l) increase	<0.5 ml/kg/h for 6–12 h
2	2.0–2.9 times baseline	<0.5 ml/kg/h for≥12 h
3	3.0 times baseline, or≥4.0 mg/dl (353.6 μmol/l), or initiation of RRT, or < 18 years, eGFR <35 ml/min per1.73 m^2	<0.3 ml/kg/h for≥24 h or anuria for ≥12 hours