Role of STAT3 Expression in Thyroid Cancer: A Meta-Analysis and Systematic Review Based on the Chinese Population
Table 2
Association between STAT3 expression and clinical features of thyroid cancer patients in meta-analysis.
Factors
Studies (n)
Analytical model
OR (95%CI)
P value
Heterogeneity
I2
Ph
Age (<45 vs ≥ 45)
4
REM
0.54 (0.21, 1.36)
0.191
64.00
0.039
Sex (male vs female)
4
FEM
0.88 (0.54, 1.44)
0.609
0
0.898
Tumor size (≤1 cm vs. > 1 cm)
2
FEM
0.13 (0.05, 0.33)
<0.001
0
0.743
Tumor metastasis (yes vs. no)
6
REM
2.83 (1.08, 7.46)
0.035
80.70
<0.001
Capsular invasion (yes vs. no)
2
REM
2.98 (0.23, 38.29)
0.403
89.60
0.002
TNM stage (I-II vs. III-IV)
3
REM
0.40 (0.24, 0.67)
<0.001
82.10
0.004
Tumor multiplicity (single vs. multiplicity)
2
REM
0.25 (0.003, 19.28)
0.533
86.00
0.008
P values were obtained by using the “METAN” program in Stata 14.0; P value 0.05 was considered as statistically significant. FEM, fixed-effects model; REM, random-effects model; TNM, tumor node metastasis; OR, odds ratio; CI, confidence interval. Bold fonts indicate statistical differences.
