Research Article
[Retracted] High CHAF1A Expression Levels Are Positively-Correlated with PD-L1 Expression and Indicate Poor Prognosis in Gastric Cancer
Table 5
Univariate cox regression analysis of 140 gastric cancer patients.
| Parameters | Univariate analysis | value | HR (95% CI) |
| Gender | Female vs. male | 0.836 | 1.082 (0.513–2.279) |
| Age (year) | ≤ 65 vs. > 65 | 0.651 | 1.168 (0.595–2.295) |
| CHAF1A expression | Low vs. high | 0.021 | 1.175 (1.090–2.890) |
| Gastric history | No vs. yes | 0.053 | 2.719 (0.988–7.487) |
| Smoking history | No vs. yes | 0.920 | 1.036 (0.519–2.070) |
| Drinking history | No vs. yes | 0.848 | 0.927 (0.428–2.008) |
| Weight loss | No vs. yes | 0.340 | 1.398 (0.703–2.788) |
| Tumor location | Proximal | 0.662 | | Distal | | | Total | | |
| Borrmann type | I, II vs. III, IV | 0.003 | 2.864 (1.420–5.777) |
| Lauren type | Intestinal | 0.382 | | Diffuse | | | Mixed | | |
| Tumor size (cm) | ≤ 5 vs. > 5 | 0.258 | 1.491 (0.747–2.979) | Grade of differentiation poor/moderate-poor.vs.moderate/well | 0.398 | 1.341 (0.679–2.647) |
| T sstage | T1,T2 vs.T3,T4 | 0.144 | 3.387 (0.659–17.398) |
| N stage | N0,N1 vs.N2,3 | 0.001 | 3.947 (1.804–8.638) |
| M stage | M0 vs.M1 | 0.014 | 13.400 (1.692–106.142) |
| TNM stage | I,II vs. III,IV | 0.177 | 1.990 (0.733–5.400) |
| Pathological type | Adenocarcinoma with others | 0.201 | 1.904 (0.696–5.207) |
| AFP (ng/ml) | ≤ 8.1 vs.> 8.1 | 0.308 | 2.388 (0.447–12.752) |
| CEA (ng/ml) | ≤ 5 vs.> 5 | 0.006 | 3.109 (1.393–6.938) |
| CA199 (U/ml) | ≤ 37 vs.> 37 | 0.045 | 1.589 (1.011–2.496) |
| CA125 (U/ml) | ≤ 35 vs. > 35 | 0.025 | 10.806 (1.344–86.885) |
| CA50 | ≤ 25 vs. > 25 | 0.165 | 2.204 (0.723–6.728) |
| PD-L1 | Negative vs. positive | 0.777 | 1.106 (0.552–2.217) |
| HER-2 | Negative vs. positive | 0.517 | 1.406 (0.503–3.391) |
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Statistically significant ( ). |