Research Article

Ethnopharmacological-Based Validation of Polyalthia suberosa Leaf Extract in Neurological, Hyperalgesic, and Hyperactive Gut Disorders Using Animal Models

Table 6

Analgesic activity of Polyalthia suberosa on acetic acid-induced writhing in mice (mean ± SEM, n = 6).

TreatmentDoseNumber of writhing (mean ± SEM)% inhibition

Control (distilled water)10 ml kg−121.50 ± 2.9200
Standard (diclofenac sodium)10 mg kg−17.0 ± 0.5267.44%
PS-250250 mg kg−19.67 ± 1.3855.02%
PS-500500 mg kg−17.67 ± 0.7264.33%

indicates  < 0.05, indicates  < 0.01, and indicates < 0.001 when compared with control.