Repeated Yueju, But Not Fluoxetine, Induced Sustained Antidepressant Activity in a Mouse Model of Chronic Learned Helplessness: Involvement of CaMKII Signaling in the Hippocampus

Figure 1

Effective dose of Yueju in inducing antidepressant effects in ICR mice. The doses of Yueju of 1 g/kg, 1.25 g/kg, and 1.5 g/kg were used for test. (a) There were significant treatment effects on tail suspension test (TST) performed 1 hour after a single administration of Yueju or fluoxetine (F (4, 50) = 6.267, ) and (b) on forced swimming test (FST) carried out at 3 hours after administration (F (4, 54) = 3.551, ). Mice were also tested for novelty-suppressed feeding test (NSF) at 24 hours after administration of Yueju or fluoxetine ((c) and (d)), food consumption (F (4, 56) = 3.530, ), and latency (F (4, 56) = 3.317, ). There was no significant treatment effect on total distance (F (4, 45) = 0.2248, ) and time spent in central areas (F (4, 45) = 0.2663, ) of open field test (OFT) measured for 5 minutes ((e) and (f)). Data represent means ± SEM. , compared with control group (one-way ANOVA and Tukey’s post hoc test). n = 10–13/group.

(a)

(b)

(c)

(d)

(e)

(f)