Synthesis, Antioxidant, and Antidiabetic Activities of Ketone Derivatives of Succinimide

Table 2

The percent inhibition of alpha-amylase and alpha-glucosidase of the synthesized compounds.

Compound	Conc. (µg/ml)	% inhibitions (α-glucosidase)	IC50 (μg/ml)	% inhibitions (α-amylase)	IC50 (μg/ml)
BW1	500	89.08 ± 1.04^ns	10.49	81.60 ± 0.00	13.90
	250	83.45 ± 0.90^ns		75.32 ± 0.40
	125	76.58 ± 0.63^ns		71.78 ± 0.44
	62.50	70.40 ± 0.20^ns		65.08 ± 0.66
	31.25	65.80 ± 0.90^ns		57.40 ± 0.40
BW2	500	87.36 ± 0.49	10.81	78.69 ± 0.14	15.34
	250	81.34 ± 0.55		73.14 ± 0.49
	125	74.39 ± 0.49		67.44 ± 0.15
	62.50	68.47 ± 0.52		63.72 ± 0.11
	31.25	62.44 ± 0.55		55.85 ± 0.17
BW3	500	77.85 ± 2.24	12.15	75.35 ± 0.89	18.20
	250	72.08 ± 0.47		71.36 ± 1.15
	125	67.90 ± 0.96		67.62 ± 0.03
	62.50	63.28 ± 0.57		62.16 ± 0.12
	31.25	57.47 ± 0.56		54.67 ± 0.35
Acarbose	500	92.23 ± 0.22	8.20	87.75 ± 0.42	10.35
	250	86.45 ± 0.90		82.47 ± 0.71
	125	80.90 ± 0.60		76.20 ± 0.49
	62.50	73.00 ± 0.30		69.42 ± 1.55
	31.25	67.90 ± 0.45		63.62 ± 0.58

All values are taken as mean ± SEM (n = 3), and two-way ANOVA followed by Bonferroni test were followed. Values significantly different as compared to standard drug; , , , and ns: not significant.