Synthesis, Antioxidant, and Antidiabetic Activities of Ketone Derivatives of Succinimide

Table 4

In vivo results of synthesized compounds against the standard drug.

S.no	Groups		Dose μg/kg	Blood glucose level (mg/dl)					Decrease in blood glucose after 15 days (mg/dl)	Change in body weight (Gm)
				0 day	4^th day	7^th day	10^th day	15^th day
1	Diabetic control		0.35 ml	478	483	501	514	527	−49	−13.7
2	Normal control saline		0.35	125	111	103	96	91	34
3	Glibenclamide		0.5	473	303	257	212	198	275	+10.3
4	BW1	1	500	412	388	372	312	291	121	+7.1
		2	250	421	397	345	219	214	207	+5.7
		3	125	443	431	413	401	394	49	+4.1
		4	62.5	380	371	365	351	346	34	+4.3
		5	31.25	418	408	399	382	375	33	+2.3
5	BW2	1	500	456	402	361	303	257	199	+7.4
		2	250	466	461	443	407	355	111	+3.4
		3	125	437	431	422	394	369	68	−3.7
		4	62.5	386	359	349	336	328	58	−4.6
		5	31.25	452	448	431	425	417	35	−6.8
6	BW3	1	500	430	420	401	387	381	49	+2.5
		2	250	431	419	411	403	396	35	−5.1
		3	125	387	437	430	424	416	−29	+5.3
		4	62.5	443	465	478	493	499	−56	−6.2
		5	31.25	439	446	457	468	478	−39	−8.4