Evidence-Based Complementary and Alternative Medicine

Research Article

Efficacy and Safety of Yangyin Shuxin Decoction—a Chinese Herbal Medicine Formula For Heart Failure with Preserved Ejection Fraction: A Randomized Controlled Trial

Table 4

Comparison of laboratory tests in the YYSX group and control group between baseline and 2 weeks.


Variables	YYSX group (n = 31)			Control group (n = 32)
Variables	Baseline	Week 2	Pa	Baseline	Week 2	Pa	Pb

SBP (mmHg)	133.23 ± 14.94	130.13 ± 15.64	0.218	139.94 ± 17.68	132.16 ± 18.21	0.007	0.638
DBP (mmHg)	75.58 ± 10.26	73.23 ± 8.72	0.141	81.28 ± 10.86	75.09 ± 9.05	<0.001	0.408
HR (bpm)	69.16 ± 14.56	70.61 ± 14.48	0.389	70.38 ± 12.87	69.34 ± 10.33	0.453	0.690
RBC (×10⁹/L)	4.29 ± 0.39	4.37 ± 0.46	0.250	4.37 ± 0.50	4.32 ± 0.48	0.121	0.662
WBC (×10⁹/L)	5.89 ± 1.30	5.99 ± 1.42	0.528	6.22 ± 1.39	6.13 ± 1.43	0.697	0.702
HGB (g/L)	129.65 ± 13.74	132.06 ± 14.91	0.193	132.88 ± 14.84	132.34 ± 14.25	0.552	0.938
PLT (×10⁹/L)	222.55 ± 48.39	224.35 ± 52.50	0.691	226.41 ± 67.05	227.69 ± 66.97	0.890	0.827
ALT (U/L)	22.61 ± 14.12	22.49 ± 13.55	0.906	20.08 ± 10.45	19.46 ± 8.71	0.541	0.294
Cr (μmol/L)	35.35 ± 27.60	27.97 ± 20.91	0.025	51.58 ± 94.92	41.99 ± 70.16	0.293	0.290
BUN (mmol/L)	6.36 ± 2.94	6.53 ± 2.76	0.550	5.39 ± 1.45	5.71 ± 1.39	0.160	0.141
K⁺ (mmol/L)	4.24 ± 0.54	4.25 ± 0.49	0.838	4.09 ± 0.36	4.18 ± 0.31	0.207	0.460
Na⁺ (mmol/L)	142.11 ± 2.05	141.69 ± 2.71	0.178	142.71 ± 1.85	143.08 ± 1.56	0.252	0.015
Cl⁻ (mmol/L)	103.24 ± 4.25	102.86 ± 4.60	0.426	104.34 ± 2.90	104.59 ± 2.77	0.600	0.075

Data are expressed by mean ± SD. SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; RBC, red blood cell; WBC, white blood cell; HGB, hemoglobin; PLT, platelets; ALT, alanine aminotransferase; Cr, creatinine; BUN, blood urea nitrogen; Na⁺, Na⁺ concentrations; K⁺, K⁺ concentrations; Cl⁻, Cl⁻ concentrations. “a” refers to the analysis of paired T-test. Comparison between baseline versus week 2. “b” refers to adjusted treatment differences estimates from an analysis of ANCOVA test, with intervention condition as the group factor and preintervention value as a covariate. Comparison between YYSX group versus control group in postintervention.