Research Article

Treatment of the Gastroesophageal Reflux Disease with Chinese Herbal Medicine (BanxiaXiexin Decoction): Evidence from Meta-Analysis

Table 2

General characteristics of the included reviews.

StudiesDiagnosticcriteriaTrials
(subjects)
GERD
Classification
Experimental InterventionControl
Intervention
DurationFollow-up periodQuality
assessment
Results summary

Yu [19]①, ②13 (1089)NERD, REBXDWM4–8 weeksNACochrane CriteriaBXD was more effective to treat GERD than the optimal combination of WM.
Chen [20]NA24 (2002)NERD, REBXDWMUnclearNAJada scaleBXD was superior to WM alone in the treatment of GERD, but there was no significant difference in gastroscopy results or on the occurrence of adverse reactions.
Dai [21]31 (1210)NERD, REBXDWM4 weeks- 8 monthsNACochrane CriteriaBXD showed a potential benefit to GERD patients, but further research is needed due to methodological quality and sample size limitations.
Zheng [22]NA11 (1305)NERD, REBXDWM4–8 weeksNACochrane CriteriaBXD treatment improved total effective and recurrence rates for GERD as compared with those of the control group.
Qi [23]NA27 (2300)NERD, REBXDWM4–8 weeks3 or 6 monthsCochrane CriteriaThe use of BXD tin the treatment of GERD was superior to WM alone in terms of cure rate and total effective rate.
Guo [24]NA12 (914)NERD, REBXDWM4–8 weeksNACochrane CriteriaBXD was superior than conventional WM to treat GERD without inducing severe adverse reactions.

①: Consensus Opinion on GERD in China [25]; ②: Chinese Herbal Medicine New Medicine ClinicalResearch Guiding Principle [26]. BXD : Banxia Xiexin decoction; NERD: nonerosive reflux disease; RE: reflux esophagitis; WM : Western medicine; NA: not applicable.