Evidence-Based Complementary and Alternative Medicine

Research Article

Effects of Cannabidiol on Parkinson’s Disease in a Transgenic Mouse Model by Gut-Brain Metabolic Analysis

Table 4

Significantly enriched terms in the DEMs bioinformatics analysis and the corresponding involved DEMs.


DEMs set	Analysis (database)	Terms (≥2 DEMs)	Involved metabolites	Sig.

bM	Enrichment/pathway (SMPDB & KEGG)	Ketone body/butanoate metabolism	Succinate; (R)-3-hydroxybutyric acid
		Beta-alanine metabolism	Pantothenate; 3-methylhistidine
		Arginine and proline metabolism	Phosphocreatine; 4-guanidinobutyric acid
bD	Pathway (KEGG)	Arginine and proline metabolism	Phosphocreatine; L-proline
	Pathway (KEGG)	Glycerophospholipid metabolism	1-Acyl-sn-glycero-3-phosphocholine; sn-Glycero-3-phosphocholine
	Enrichment/pathway (KEGG/SMPDB)	Pantothenate and CoA biosynthesis	Pantothenate; L-cysteine
fM	Enrichment/pathway (KEGG)	Fatty acid biosynthesis	Capric acid; palmitic acid
fD	Pathway (SMPDB/KEGG)	Fatty acid biosynthesis	Capric acid; palmitic acid; acetylglycine
	Enrichment (human feces)	Obesity	L-glutamate; vaccenic acid
	Enrichment (SMPDB/KEGG)	Arginine biosynthesis	L-glutamate; N-acetyl-L-glutamate
	Enrichment (SMPDB/KEGG)	Histidine metabolism	L-glutamate; 3-methylhistidine 1-methylhistidine

bM: brain samples, group M versus C; bD: brain samples, group D versus M; fM: feces samples, group M versus C; fD: feces samples, group D versus M. The focused DEMs and the corresponding significant terms were in form of bold. Significance (Sig.): ; ; .