Mechanism and Active Components of Qingre Lidan Tablets Alleviate Intrahepatic Cholestasis by Activating the Farnesoid X Receptor

Figure 4

Screening and verification of active monomers from QLT-agitated FXR. (a). Positive ion mode and QLT ester extract; (b). negative ion mode and QLT ester extract; (c). positive ion mode and QLT n-butanol extract; (d). negative ion mode and QLT n-butanol extract; (e). activating activity of each component of QLT ester extract on FXR detected by dual-luciferase reporter gene system; (f). activating activity of each component of alcohol extract of QLTs on FXR detected by dual-luciferase reporter gene system; (g). monomer verification of active ingredients (n = 6, ^## compared with the control group); (1) baicalein, (2) wogonin, (3) skullcapflavone II, (4) emodin, (5) dibutyl phthalate, and (6) diisooctyl phthalate.

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