Effect of Secreted Frizzled-Related Protein 5 in Mice with Heart Failure

Figure 5

Effects of recombinant SFRP-5 proteins on the pathological structure of the myocardium in ISO-induced HF in mice. The NS group (a) showed the normal histological structure of the cardiac muscle. The ISO group (b) and ISO + PBS group (c) showed severe cardiac insult, marked inflammatory cell infiltration, and edema between muscle fibers. The ISO + SFRP5 group (d) demonstrated almost normal cardiac muscles.