Evidence-Based Complementary and Alternative Medicine / 2022 / Article / Tab 1 / Research Article
Exploration in the Mechanism of Zhisou San for the Treatment of Cough Variant Asthma Based on Network Pharmacology Table 1 Eight targets with the highest score from core targets and the binding ability with active compounds of Zhisou San in treating cough variant asthma by molecular docking.
Target proteins Symbol Compound Herbs Binding energy (kcal/mol) β 2 Adrenergic receptorβ 2-ADR7-Methoxy-3-methyl-2,5-dihydroxy-9,10-dihydrophenanthrene BB −6.09 Stigmasterol JJ; BB −7.44 Delta-type opioid receptor OPRD1 Medicarpin GC −6.18 Shinpterocarpin GC −5.78 C-X-C motif chemokine 10 CXCL10 Quercetin JJ; ZW; GC −6.62 Muscarinic acetylcholine receptor M2 CHRM2 2-Oxostenine BB −7.99 Beta-sitosterol JJ; ZW; BB; BQ −7.68 Bisdehydroneotuberostemonine BB −7.97 Didehydrotuberostemonine BB −8.27 Kaempferol ZW; GC −6.88 Medicarpin GC −6.79 Quercetin JJ; ZW; GC −5.19 Sessilifoline B BB −7.15 Stemoninine B BB −8.69 Stigmasterol JJ; BB −7.19 Tuberostemonine C BB −7.02 D1 dopamine receptor DRD1 Bisdehydroneotuberostemonine BB −9.38 Prostaglandin E2 receptor EP3 subtype PTGER3 luteolin JJ; ZW; JG −5.92 Quercetin JJ; ZW; GC −5.12 Mu-type opioid receptor OPRM1 7-Methoxy-2-methyl isoflavone GC −5.77 7-Methoxy-3-methyl-2,5-dihydroxy-9,10-dihydrophenanthrene BB −6.0 Beta-sitosterol JJ; ZW; BB; BQ −7.35 Bisdehydroneotuberostemonine BB −7.35 Didehydrotuberostemonine BB −7.52 Inermine GC −6.32 Medicarpin GC −5.74 Quercetin JJ; ZW; GC −5.03 Shinpterocarpin GC −6.97 Tuberostemonine C BB −7.26 Intercellular adhesion molecule 1 ICAM1 Kaempferol ZW; GC −6.36 Luteolin JJ; ZW; JG −6.66 Quercetin JJ; ZW; GC −6.46
