Systemic Administration of Neutral Electrolyzed Saline as a Novel Treatment for Rheumatoid Arthritis Reduces Mechanical and Inflammatory Damage to the Joints: Preclinical Evaluation in Mice

<div>Schematic representation of the study in the rheumatoid arthritis mouse model. After the induction of the pathology (collagen-induced arthritis (CIA) model), the animals were randomized into three groups, one with a placebo and the others with the administration of 20<i>µ</i>l (NES20) or 40 <i>µ</i>l (NES40) of neutral electrolyzed saline, all of them daily. An additional group remained without disease induction (healthy) or treatment. After 30 days of treatment and follow-up, the animals were sacrificed for histopathological analysis of their joint disease. Blood samples were also taken for IL-6 analysis.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 1: Systemic Administration of Neutral Electrolyzed Saline as a Novel Treatment for Rheumatoid Arthritis Reduces Mechanical and Inflammatory Damage to the Joints: Preclinical Evaluation in Mice 

Figure 1 | Systemic Administration of Neutral Electrolyzed Saline as a Novel Treatment for Rheumatoid Arthritis Reduces Mechanical and Inflammatory Damage to the Joints: Preclinical Evaluation in Mice 