Systemic Administration of Neutral Electrolyzed Saline as a Novel Treatment for Rheumatoid Arthritis Reduces Mechanical and Inflammatory Damage to the Joints: Preclinical Evaluation in Mice

Table 1

Intergroup analysis of weight variations.

Parameter	Placebo	NES	value^†
	Median (Q1–Q3), N = 10 in each group
Week 1	25.37 (24.85–29.65)	23.82 (22.27–29.31)	0.082
Week 2	24.76 (23.96–30.29)	24.06 (22.33–29.47)	0.199
Week 3	24.95 (24.46–30.94)	24.37 (23.19–29.29)	0.186
Week 4	26.99 (25.78–29.11)	24.34 (23.63–29.10)	0.082

NES : neutral electrolyzed saline; Q1 and Q3: 25th and 75th percentiles. Weight is expressed in grams. ^†Mann–Whitney U-test. .Statistical significance: . Two-tailed P values are shown.