Jieduan–Niwan Formula Ameliorates Oxidative Stress and Apoptosis in Acute-on-Chronic Liver Failure by Suppressing HMGB1/TLR-4/NF-<i>κ</i>B Signaling Pathway: A Study In Vivo and In Vitro

<div>TdT-mediated dUTP Nick end labeling (TUNEL) staining to detect the effect of JDNW on the apoptosis rate of hepatocytes. (a, b) The effect of treatment at different time points on hepatocyte apoptosis in ACLF rats: 10 random fields/per slice, 3 random slices/per sample, representative of 5–6 rats/group. (c, d) Effects of JDNW serum on apoptosis of L02 cells induced by D-GaLN. Data are presented from three independent experiments. TUNEL-positive cells (green fluorescence). 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Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: Jieduan–Niwan Formula Ameliorates Oxidative Stress and Apoptosis in Acute-on-Chronic Liver Failure by Suppressing HMGB1/TLR-4/NF-<i>κ</i>B Signaling Pathway: A Study In Vivo and In Vitro 

Figure 5 | Jieduan–Niwan Formula Ameliorates Oxidative Stress and Apoptosis in Acute-on-Chronic Liver Failure by Suppressing HMGB1/TLR-4/NF-κB Signaling Pathway: A Study In Vivo and In Vitro 