Effects of Sensitized Sorafenib with a Paeoniflorin and Geniposide Mixture on Liver Cancer via the NF-κB-HIF-2α-SerpinB3 Pathway

Figure 5

The antitumor effect of PFGS combined with Sor on SR cells. (a) PFGS inhibited the viability of SR cells in a dose-dependent manner. Cell viability was investigated using the CKK-8 assay (n = 6). (b, c) PFGS combined with Sor inhibited the viability of SR cells in a dose-dependent manner. Cell viability was investigated using the CKK-8 assay (n = 6). (d) Invasion of SR cells in the microporous membrane of the Transwell chamber (n = 3). (e) The protein expression of NF-κB p65, HIF-2α, and SerpinB3 in SR cells (n = 3). Data are presented as the mean ± SD. compared with the control group; compared with the control group; ^&& compared with the 6 μg/mL PFGS combined with the same concentration of Sor group; ^## compared with the control group; ⁺CDI<1 had a synergistic effect;⁺⁺CDI<0.7 had a marked synergistic effect.

(a)

(b)

(c)

(d)

(e)