Ethyl Acetate Fraction of <i>Hedyotis diffusa Willd</i> Induces Apoptosis via JNK/Nur77 Pathway in Hepatocellular Carcinoma Cells

<div>Antitumor activity of different extracts of HDW in zebrafish xenograft model. EHDW inhibited the proliferation of Hep3B cells in vivo. Hep3B cell-bearing zebrafish were treated with HHDW (a), NHDW (b), EHDW (c), PHDW (d), or sorafenib (0.25 <i>μ</i>M) for 72 h and then CM-Dil-labeled Hep3B cells in yolk sac were visualized using a fluorescence microscope. Left: bright field, middle: CM-Dil-staining cells, right: merge. Bar: 200 <i>μ</i>m. (e–h). 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Evidence-Based Complementary and Alternative Medicine

fig2

Figure 2

Figure 2: Ethyl Acetate Fraction of <i>Hedyotis diffusa Willd</i> Induces Apoptosis via JNK/Nur77 Pathway in Hepatocellular Carcinoma Cells 

Evidence-Based Complementary and Alternative Medicine

Ethyl Acetate Fraction of Hedyotis diffusa Willd Induces Apoptosis via JNK/Nur77 Pathway in Hepatocellular Carcinoma Cells

Figure 2