Research Article
Magnoflorine Attenuates Cerebral Ischemia-Induced Neuronal Injury via Autophagy/Sirt1/AMPK Signaling Pathway
Figure 3
Effect of magnoflorine on neuronal damage and oxidant stress following cerebral ischemia in rats. Representative images of the Nissl staining in the cerebral cortex (a) and quantification the injured neurons (c) were shown. Brain sections were stained with NeuN (green) and DAPI (blue) to monitor the density of neurons. (b) Representative immunofluorescent staining in the cerebral cortex of rats. (d) The neuron density was quantified. (e-f) The concentrations of NO, MDA, GSH, GSH-PX in the serum or brain tissues were detected. Scale bar, 100 µm. Values are mean ± SEM, n = 5 per group. , , . MNF, magnoflorine; BBR, berberine; MCAO, middle cerebral artery occlusion; NO, nitric oxide; MDA, malondialdehyde; GSH, glutathione; PX, peroxidase.
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