The Traditional Chinese Medicine Hua Tuo Zai Zao Wan Alleviates Atherosclerosis by Deactivation of Inflammatory Macrophages

Figure 4

HTZZW inhibited NF-κB RNA m6A modifications and induced a decrease in the expression level of NF-κB RNA. (a) Western blotting results of the expression levels of NF-κB and phosphorylated NF-κB (p-NF-κB) in cell nuclei. vs. saline group; t-test; n = 4. (b) Results of immunofluorescence staining of the aortic arch of mice. (c) RIP-PCR results. vs. blank ctrl group; ^## vs. saline group; t-test; n = 4. (d) The mechanism by which HTZZW alleviates inflammation and AS through the inhibition of NF-κB RNA m6A modifications in Mφ1.

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