Electroacupuncture Reduces Fibromyalgia Pain by Attenuating the HMGB1, S100B, and TRPV1 Signalling Pathways in the Mouse Brain

Figure 6

Schematic illustration of neuronal and non-neuronal mechanisms underlying EA-mediated analgesic effect on ICS-induced fibromyalgia pain. The summary diagram shows the importance of and mechanisms involving glial cells (astrocytes and microglia) and TRPV1 in fibromyalgia pain. EA inhibits HMGB1 and S100B release from non-neuronal cells or directly inhibits TRPV1 on the plasma membrane. Mice with a TRPV1 gene deletion (Trpv1^−/−) have the same phenotype than mice treated with EA.