Effect of Chaihu Shugan Pills on the Pharmacokinetics of Duloxetine and its Metabolite 4-Hydroxyduloxetine in Beagle Dogs: A Herb-Drug Interaction Study

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Chinese name</td><td class="align_center">Herb name</td><td class="align_center">Botanical name</td><td class="align_center">Ratio (%)</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">Chai-hu</td><td class="align_center">Radix bupleuri</td><td class="align_center"><i>Bupleurum</i> Chinese DC.</td><td class="align_center">19.05</td></tr><tr><td class="align_left">Chen-pi</td><td class="align_center">Pericarpium citri reticulatae</td><td class="align_center"><i>Citrus reticulata</i> Blanco</td><td class="align_center">19.05</td></tr><tr><td class="align_left">Chuanxiong</td><td class="align_center">Rhizoma chuanxiong</td><td class="align_center"><i>Ligusticum chuanxiong</i> Hort.</td><td class="align_center">14.29</td></tr><tr><td class="align_left">Xiang-fu</td><td class="align_center">Rhizoma cyperi</td><td class="align_center"><i>Cyperus rotundus</i> L.</td><td class="align_center">14.29</td></tr><tr><td class="align_left">Zhi-qiao</td><td class="align_center">Fructus aurantii</td><td class="align_center"><i>Citrus aurantium</i> L.</td><td class="align_center">14.29</td></tr><tr><td class="align_left">Shao-yao</td><td class="align_center">Chinese herbaceous peony</td><td class="align_center"><i>Paeonia lactiflora</i> Pall.</td><td class="align_center">14.29</td></tr><tr><td class="align_left">Zhi-gan-cao</td><td class="align_center">Roasted licorice</td><td class="align_center"><i>Glycyrrhiza uralensis</i> Fisch.</td><td class="align_center">4.76</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>The Chinese, herbal, and botanical names of the corresponding herb in CHSG.</div>

Evidence-Based Complementary and Alternative Medicine

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Table 1

Table 1: Effect of Chaihu Shugan Pills on the Pharmacokinetics of Duloxetine and its Metabolite 4-Hydroxyduloxetine in Beagle Dogs: A Herb-Drug Interaction Study 

Table 1 | Effect of Chaihu Shugan Pills on the Pharmacokinetics of Duloxetine and its Metabolite 4-Hydroxyduloxetine in Beagle Dogs: A Herb-Drug Interaction Study 