Effect of Chaihu Shugan Pills on the Pharmacokinetics of Duloxetine and its Metabolite 4-Hydroxyduloxetine in Beagle Dogs: A Herb-Drug Interaction Study

Table 2

UPLC Gradient elution procedures.

Time (min)	Flow rate (mL/min)	0.1% formic (%)	Acetonitrile (%)
0	0.4	90	10
0.5	0.4	90	10
1.0	0.4	10	90
1.4	0.4	10	90
1.5	0.4	90	10
2.0	0.4	90	10