Effect of Chaihu Shugan Pills on the Pharmacokinetics of Duloxetine and its Metabolite 4-Hydroxyduloxetine in Beagle Dogs: A Herb-Drug Interaction Study

Table 3

Precision and accuracy of duloxetine and 4-hydroxyduloxetine in beagle dog plasma (n = 6, Mean ± SD).

Analytes	Added (ng/mL)	Intraday				Interday
		Mean ± SD	RSD (%)	RE (%)	Mean ± SD	RSD (%)	RE (%)
Duloxetine	2.5	2.53 ± 0.20	8.01	1.18	2.48 ± 0.19	7.73	-0.61
	100	99.43 ± 7.58	7.62	-0.58	101.03 ± 6.30	6.23	1.03
	750	742.22 ± 25.38	3.42	−1.04	753.09 ± 31.82	4.22	0.41
4-Hydroxyduloxetine	0.25	0.247 ± 0.02	7.97	−1.33	0.256 ± 0.02	7.85	2.22
	10	10.29 ± 0.70	6.76	2.85	9.96 ± 0.60	6.04	-0.37
	75	75.13 ± 2.44	3.25	0.17	75.58 ± 2.80	3.71	0.78