Effect of Chaihu Shugan Pills on the Pharmacokinetics of Duloxetine and its Metabolite 4-Hydroxyduloxetine in Beagle Dogs: A Herb-Drug Interaction Study

Table 4

Recoveries and ME of duloxetine and 4-hydroxyduloxetine in beagle dog plasma.

Analytes	Added (ng/mL)	Recovery (%)	RSD (%)	ME (%)	RSD (%)
Duloxetine	2.5	81.53 ± 2.56	3.14	98.35 ± 4.56	4.64
	100	83.73 ± 4.09	4.89	101.64 ± 4.95	4.87
	750	84.05 ± 3.06	3.65	102.57 ± 4.08	3.98
4-Hydroxyduloxetine	0.25	79.97 ± 3.66	4.57	102.62 ± 4.02	3.91
	10	80.73 ± 4.46	5.53	98.88 ± 4.46	4.51
	75	82.24 ± 3.05	3.71	101.44 ± 4.30	4.24