Effect of Chaihu Shugan Pills on the Pharmacokinetics of Duloxetine and its Metabolite 4-Hydroxyduloxetine in Beagle Dogs: A Herb-Drug Interaction Study

Table 5

Stability results of duloxetine and 4-hydroxyduloxetine in beagle dog plasma in different conditions.

Analytes	Added (ng/mL)	Room temperature, 4 h		Autosampler 4°C, 6 h		Three freeze-thaw		−20 °C, 4 weeks
		RSD (%)	RE (%)	RSD (%)	RE (%)	RSD(%)	RE(%)	RSD(%)	RE(%)
Duloxetine	2.5	8.16	−3.07	9.59	2.47	6.39	−1.73	8.65	1.80
	100	4.61	1.05	6.91	−0.36	4.54	1.34	3.79	−1.79
	750	3.88	1.16	4.76	0.81	3.93	-0.73	1.72	0.61
4-Hydroxyduloxetine	0.25	8.84	−3.33	10.93	2.67	6.71	−2.00	6.45	1.33
	10	4.33	1.37	6.69	−0.15	4.61	1.18	3.79	−1.73
	75	3.31	1.08	4.74	0.84	3.85	−0.68	2.40	0.27