Effect of Chaihu Shugan Pills on the Pharmacokinetics of Duloxetine and its Metabolite 4-Hydroxyduloxetine in Beagle Dogs: A Herb-Drug Interaction Study

Table 6

The main pharmacokinetic parameters of duloxetine and 4-hydroxyduloxetine in the control and experimental group (n = 6, mean ± SD).

Parameters	Duloxetine		4-Hydroxyduloxetine
	Control group	Experimental group	Control group	Experimental group
t1/2 (h)	13.58 ± 4.26	10.17 ± 3.01	11.23 ± 1.79	7.97 ± 2.05
Tmax (h)	1.17 ± 0.26	3.50 ± 1.38	1.67 ± 0.26	4.33 ± 1.51
MRT(0-t) (h)	5.37 ± 1.10	7.37 ± 2.17	7.73 ± 0.81	9.60 ± 2.40
MRT(0-∞) (h)	7.03 ± 1.63	8.39 ± 1.86	9.02 ± 1.26	10.32 ± 2.49
Cmax (ng/mL)	469.14 ± 185.61	237.70 ± 95.13	47.70 ± 19.83	13.48 ± 7.07
CLz/F (L/h/kg)	1.75 ± 0.69	2.02 ± 0.68	13.41 ± 8.34	25.39 ± 15.25
AUC(0-t) (ng·h/mL)	1262.10 ± 467.36	1096.96 ± 463.92	178.37 ± 70.00	92.57 ± 31.31
AUC(0-∞) (ng·h/mL)	1291.33 ± 466.82	1113.04 ± 461.70	183.29 ± 71.06	93.88 ± 31.49

Note. Compared with the control group, and .