Sweet Wormwood and Tortoise Shell Decoction (Thanh Hao Miet Giap Thang) Induces DNA Damage, S-Phase Arrest, and Apoptosis in MCF-7 Cells via ATR-CHK1 Signaling Pathway
Table 2
THMGT induced the apoptosis of MCF-7 cells.
Proportion of cell population (%) determined at different time points
3 h
6 h
9 h
Nontreated
THMGT
Nontreated
THMGT
Nontreated
THMGT
Survive
84.1 ± 4.7
80.5 ± 10.7
82.5 ± 3.4
60.3 ± 7.9
90.0 ± 5.3
44.1 ± 2.8
E-apo
6.9 ± 3.8
8.0 ± 9.5
5.4 ± 4.1
8.0 ± 4.8
4.3 ± 4.8
15.6 ± 13.3
L-apo
7.1 ± 2.1
9.1 ± 3.2
8.8 ± 1.5
26.3 ± 10.4
4.3 ± 1.5
33.9 ± 7.8
Necrosis
1.9 ± 2.6
2.4 ± 2.9
3.3 ± 2.6
5.4 ± 2.7
1.4 ± 0.6
6.4 ± 4.1
E, early; L, late; statistical analyses were performed using a two-tailed Student's t-test. ; . Data are shown as mean ± SD of three independent experiments.
