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| Study | Study period | Age median (IQR) | Study type | Patients | Sample size (study/ control) | Albumin (%) | Crystalloid | Follow-up | Outcome (study vs. control, %) | Risk |
|
| Chou et al | 2009 | N/A | RC | Sepsis | 133 (52/81) | 25% albumin | N/A | 28-day mortality | 48.1% (25/52) vs. 51.9% (42/81) | M |
| Annane et al | 2013 | Study: 63 (50–76) Control: 63 (50–75) | RCT | Sepsis | 616 (59/557) | 4%, 5%, 20% or 25% albumin | Isotonic or hypertonic saline | 28-day and 90-day mortality | 28-day: 32.2% (19/59) vs. 28.2% (157/557) 90-day: 37.3% (22/59) vs. 35.4% (197/557) | L |
| Park et al | 2019 | Study: 62 (51–70) Control: 61 (52–70) | RCT | Sepsis and Septic shock | 360 (180/180) | 4% albumin | Lactated Ringer’s | 7-day and 28-day mortality | 7-day: 25.6% (46/180) vs. 22.2% (40/180) 28-day: 53.3% (96/180) vs. 46.1% (83/180) | L |
| Caironi et al | 2014 | Study: 70 (57–77) Control: 69 (59–77) | RCT | Sepsis and Septic shock | 1810 (903/907) | 20% albumin | N/A | 28-day and 90-day mortality | 28-day: 31.8% (285/895) vs. 32.0% (288/900) 90-day: 41.1% (365/888) vs. 43.6% (389/893) | L |
| Finfer et al | 2011 | Study: 60.5 ± 17.2 Control: 61.0 ± 17.1 | RCT | Sepsis and Septic shock | 1218 (603/615) | 4% albumin | 0.9% sodium chloride | 28-day mortality | 30.7% (185/603) vs. 35.3% (2174/615) | L |
| Liu et al | 2021 | Study: 67 (56–77) Control: 67 (54–77) | RC | Sepsis and Septic shock | 835 (286/549) | 5% or 20% albumin | N/A | 28-day mortality | 35.7% (102/286) vs. 31.7% (174/549) | M |
| Alexander et al | 2021 | Study: 59 (51–67) Control: 59 (50–68) | RC | Septic shock | 360 (335/335) | 25% albumin | N/A | 28-day mortality | 46.9% (157/335) vs. 44.8% (150/335) | M |
| Charpentier et al | 2011 | N/A | RCT | Septic shock | 792 (399/393) | 20% albumin | 0.9% sodium chloride | 28-day mortality | 24.1% (96/399) vs. 26.2% (103/393) | L |
| Veneman et al | 2004 | N/A | RCT | Sepsis | 31 (8/25) | 20% albumin | 0.9% sodium chloride | 28-day mortality | 62.5% (5/8) vs. 56.0% (14/25) | H |
| Philips et al | 2021 | Study: 49.4 ± 12.1 Control: 48.2 ± 10.6 | RCT | Sepsis and Septic shock | 308 (154/154) | 5% albumin | 0.9% sodium chloride | 7-day mortality | 43.5% (87/154) vs. 38.3% (95/154) | M |
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