Aloe-Emodin Ameliorates Diabetic Nephropathy by Targeting Interferon Regulatory Factor 4

Figure 1

Upregulation of IRF4 in the specimens of patients with DN. (a) Heatmap analysis for the comparison of mRNA expression profiles between normal control and DN samples. (b) Volcano plot for differentially expressed mRNAs between normal control and DN samples. Red and green plots indicate upregulated and downregulated miRNAs, respectively. (c) DN-related PPI hubs as revealed by the PPI network analysis of the upregulated mRNAs. The topological PPI network indicates that IRF4 is a core node gene in regulating DN. DN, diabetic nephropathy; PPI, protein-protein interaction.

(a)

(b)

(c)