Aloe-Emodin Ameliorates Diabetic Nephropathy by Targeting Interferon Regulatory Factor 4

Figure 4

Receptor-ligand interactions of the compound. (a) Protocol flowchart of the IRF4 inhibitor screening strategy. Ae was screened through HTV, SP, and XP screening methods. (b) 2D binding model of the IRF4-Ae complex through the molecular docking method. (c) Effective binding of Ae to the active pocket of IRF4. Results showed that Ae interacted with three key amino acid residues of IRF4. TCM, traditional Chinese medicine; HTV, high-throughput virtual screening; SP, standard precision; XP, extra precision.

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