Research Article

Exploring Active Compounds and Mechanisms of Angong Niuhuang Wan on Ischemic Stroke Based on Network Pharmacology and Molecular Docking

Table 1

Information of the candidate active ingredients of ANW.

HerbActive ingredients

Bovis CalculusOleanolic acid, cherianoine, CLR, bilirubin, methyl(4R)-4-[(3R,5S,7S,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl- 2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate, methyl desoxycholate, chenodeoxycholic acid, deoxycholic acid, ZINC01280365, biliverdin, cholic acid, choline, deoxycorticosterone, ergosterol, ergotamine, glycocholic acid, lithocholic acid, ursodeoxycholic acid, hyodeoxycholic acid
Coptidis RhizomaBerberine, columbamine, fagarine, berberrubine, DPEC(5,8-dihydroxy-2-(2-phenylethyl)chromone), epiberberine, groenlandicine, (R)-canadine, berlambine, magnograndiolide, palmatine, coptisine, tetrandrine, Worenine, Pycnamine, jatrorrhizine, quercetin
Scutellariae RadixAcacetin, wogonin, (2R)-7-hydroxy-5-methoxy-2-phenylchroman-4-one, β-patchoulene, baicalein, 5,8,2′-Trihydroxy-7-methoxyflavone, dihydrobaicalin_qt
Salvigenin, 5,2′,6′-Trihydroxy-7,8-dimethoxyflavone, dihydrooroxylin A, skullcapflavone II, oroxylin a, panicolin, DIHYDROOROXYLIN(2beta-Phenyl-2,3- dihydro-5,7-dihydroxy-6-methoxy-4h-1-benzopyran-4-one), beta-sitosterol, sitosterol, norwogonin, 5,2′-dihydroxy-6,7,8-trimethoxyflavone, (-)-alpha-cedrene, linoleic acid, stigmasterol, dibutyl phthalate, coptisine, bis[(2S)-2-ethylhexyl] benzene-1,2-dicarboxylate, supraene, methyl palmitelaidate, methyl linolelaidate, Diop, epiberberine, patchoulene, 13-tetradecenyl acetate, moslosooflavone, 11,13-eicosadienoic acid, methyl ester, linolenic acid methyl ester, rivularin, neobaicalein, baicalin
Bubali CornuCalcium carbonate, eukeratin, ssulfocysteine, serine, isoleucine, glutamic acid, phenylalanine, histidine, cholesterol, cysteine, proline, lysine, tyrosine, arginine
Ethanolamine, aspartic acid, glycine, alanine, methionine, threonine, guanidine derivatives, guanidine
Moschusβ-Estradiol, 3,5-dihydroxybenzoic acid, 3alpha,17-dihydroxy-5beta-androstane, 3alpha-hydroxy-5alpha-androstan-17-one, 3beta,17alpha-dihydroxy-5alpha-androstane, 3beta-hydroxy-5alpha-androstan-17-one, 3beta-hydroxy-androst-5-ene-17-one, 3α-hydroxy-5β-androstan-17-one, testosterone, allantoin, serine
3β-Hydroxy-5α-androstan-17-one, 3β-hydroxy-androst-5-ene-17-one, 5 alpha-androstan-3,17-dione, 5beta-androstan-3 alpha,17beta-diol, 5α-androstan- 3,17-dione, 5α-androstane-3β,17α-diol, 5β-androstan-3,17-dione, 5β-androstan-3α,17α-diol, 5β-androstan-3α,17β-diol, alpha-estradiol, androst-4,6-diene-3,17-dione, androst-4-ene-3,17-dione, androsterone, cholesterol, decamine, estragole, morin, n-nornuciferine, normuscone, s-methyl cysteine, aspartic acid
CinnabarisMercuric sulfide, HgCl2
Gardeniae Fructus(4aS,6aR,6aS,6bR,8aR,10R,12aR,14bS)-10-Hydroxy-2,2,6a,6 b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
Ammidin, sudan III, linoleic acid, oleanolic acid, beta-sitosterol, stigmasterol, oleic acid, mandenol, supraene, methyl linoleate, methyl vaccinate, isoimperatorin
Exceparl M-OL, chrysin, ethyl oleate (NF), 5-hydroxy-7-methoxy-2-(3,4,5-trimethoxyphenyl)chromone, PANA(N-Phenyl-1-naphthylamine), gardenoside_qt, quercetin, shanzhiside_qt, kaempferol
MargaritaAluminium, calcium carbonate, cuprum, iron, manganese, silicon, zinc, magnesium, strontium, alanine, aspartic acid, leucine, serine, taurine, selenium, valine
BorneolumOleanolic acid, caryophyllene oxide, dipterocarpol, asiatic acid, bornyl acetate, beta-caryophyllene, borneol, isocembrol, D-borneol, erythrodiol, beta-humulene
Oleanolic acid-28-O-beta-D-glucopyranoside, dryocrassin, camphor, elemicin, alphitolic acid
RealgarRealgar, as2s3, As4S4
Curcumae RadixFuranodienon, linoleic acid, beta-sitosterol, sitosterol, dibutyl phthalate, oleic acid, calarene, copaene, ()-aromadendrene, aromadendrene oxide 2, alnusone
(1Ar,4aS,7R,7aR,7bR)-1,1,7-Trimethyl-4-methylidene decahydro-1h-cyclopropa(e)azulen-7-olTrans-1,7-diphenyl-1-hepten-5-ol, Junipene, ()-ledene, (4aR,5R,8 R, 8aR)-5,8-dihydroxy-3,5,8a-trimethyl-6,7,8,9-tetrahydro-4ah-benzo[f]benzofuran-4-one, curcumol, epicurzerenone, germacrone-4,5-epoxide, glechomanolide, furanodienone, isospathulenol, patchoulene, 1-phenylnaphthalene, pyrocurzerenone, trans,trans-1,7-diphenyl-1,3-heptadien-5-ol, zederone, bisdemethoxycurcumin, 1,7-diphenyl-6(E)-hepten-3one, calarenepoxide, caryophyllene oxide, (1S,3aR,4R,8aS)-7-isopropyl-1,4-dimethyl- 2,3,3a,5,6,8a- hexahydroazulene-1,4-diol, Isocurcumenol, (1S,6R,7R)-4-isopropylidene-1-methyl-7-(3-oxobutyl)norcaran-3-one, (5R,6 R)-5-isopropenyl-3,6-dimethyl-6-vinyl- 5,7-dihydrobenzofuran-4-one, (-)-isoledene, gweicurculactone, curcumenol, (3S,3aS,8aR)-3-hydroxy-5-isopropylidene-3-methyl-8-methylene-2,3a,4,8a- tetrahydro-1h-azulen-6-one, zedoarondiol, procurcumadiol, (3S,3aS,8aR)-3-hydroxy-5-isopropylidene-3,8-dimethyl-2,3a,4,8a-tetrahydro- 1h-azulen-6-one, 3-octadecenoic acid, demethoxycurcumin