Research Article
Plasma Neurofilament Light Chain Is Associated with Cognitive Impairment after Posterior Circulation Stroke
Table 1
Baseline characteristics of the participants.
| | Factors | Total | PSCI | Non-PSCI | |
| | Overall rate, n (%) | 264 (100) | 101(38.30) | 163 (61.70) | | | Sex, male, n (%) | 157 (59.47) | 55 (54.46) | 102 (62.60) | 0.191 | | Age (y), median(IQR) | 65 (51–73) | 68 (56.50–76.50) | 62 (49–71) | 0.005 | | Education level, <6 years, n (%) | 76 (28.78) | 27 (26.73) | 49 (30.06) | 0.562 | | Vascular risk factors, n (%) | | Hypertension | 144 (54.54) | 61 (60.39) | 83 (50.92) | 0.133 | | Diabetes mellitus | 73 (27.65) | 29 (28.71) | 44 (26.99) | 0.762 | | Hyperlipidemia | 52 (19.70) | 27 ( 26.73) | 25 (15.34) | 0.024 | | Atrial fibrillation | 32 (12.12) | 12 (11.88) | 20 (12.27) | 0.925 | | Smoking | 97 (36.74) | 33 (32.67) | 64 (39.26) | 0.280 | | Drinking | 62 (23.48) | 19 (18.81) | 43 (26.38) | 0.159 | | NIHSS, median (IQR) | 5 (3–8) | 7 (3–10) | 4 (2–7) | 0.001 | | Infarct volume (ml), median (IQR) | 12.87 (7.76–19.19) | 18.06 (12.56–24.14) | 11.05 (3.30–15.35) | <0.001 | | TOAST classification, n (%) | | | | 0.192 | | Large-artery atherosclerosis | 151 (57.20) | 64 (63.37) | 87 (53.37) | | | Cardioembolism | 44 (16.67) | 16 (15.84) | 28 (17.18) | | | Small vessel occlusion | 23 (8.71) | 9 (8.91) | 14 (8.59) | | | Other cause | 18 (6.82) | 7 (6.93) | 11 (6.75) | | | Undetermined | 28 (10.61) | 5 (4.95) | 23 (14.11) | | | Blood sampling time (h), median (IQR) | 26.00 (15.00–37.00) | 28.00 (19.50–40.00) | 25.00 (14.00–36.00) | 0.103 | | Plasma NfL (pg/mL), median (IQR) | 38.68 (24.61–53.85) | 49.54 (40.00–78.59) | 30.12 (19.88–43.61) | <0.001 | | HbA1c (%), median (IQR) | 5.90 (5.5–7.30) | 5.90 (5.60–7.55) | 5.90 (5.40–7.00) | 0.259 | | Hs-CRP (mg/L), median (IQR) | 3.33 (2.16–4.78) | 3.20 (2.56–4.72) | 3.48 (2.12–4.84) | 0.871 | | Homocysteine (umol/L), median (IQR) | 15.54 (11.32–21.76) | 16.45 (12.32–22.91) | 15.14 (10.13–21.70) | 0.042 | | MOCA, median (IQR) | 26.00 (23.25–27.00) | 22.00 (19.00–24.00) | 26.00 (26.00–28.00) | <0.001 |
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PSCI, poststroke cognitive impairment; IQR, interquartile range; NIHSS, National Institutes of Health Stroke Scale; TOAST, Trial of ORG 10172 in Acute Stroke Treatment; Hs-CRP, high-sensitivity C-reactive protein; MOCA, Montreal Cognitive Assessment.
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