Research Article

Clinical Efficacy Evaluation and Potential Mechanism of Zhishe Tongluo Capsule in the Treatment of Cerebral Infarction by Meta-Analysis Associated with Network Pharmacology

Table 1

Basic characteristics of included studies.

Eligible studiesAgeSample size (T/C)Intervention measuresCourse/yearOutcome index
TC

Hongying MO 2015 [18]T: 73.32 ± 7.94 C: 71.44 ± 8.23100 (50/50)Conventional therapy + ZTCConventional therapyNil
Hongying MO 2016 [19]T: 52.78 ± 2.56 C: 53.69 ± 3.2360 (30/30)Conventional therapy + atorvastatin + ZTCConventional therapy + atorvastatinT: 7.89 ± 1.80 C: 7.52 ± 1.63①③
Hongying MO 2019 [20]122 (61/61)Conventional therapy + ZTCConventional therapyNil③⑧
Deshen He 2015 [21]T: 45–79 C: 47–78116 (58/58)Conventional therapy + aspirin, atorvastatin calcium, citicoline + ZTCConventional therapy + aspirin, atorvastatin calcium, citicolineT: 0.03–0.58 C: 0.03–0.58①②
Qun Zhang 2015 [22]T: 41–80 C: 43–78350 (184/166)Conventional therapy + ZTCConventional therapy + Xiaoshuan Tongluo tabletsNil①②④⑤
Yi Chun Mao 2017 [23]T: 61.4 ± 8.7 C: 65.2 ± 8.878 (39/39)Conventional therapy + ZTCConventional therapyT: 0.03–0.25 C: 0.04–0.42①②
Yonggang Wang 2015 [24]T: 62.72 ± 12.41 C: 63.33 ± 11.71156 (78/78)Conventional therapy + three-stage rehabilitation of stroke + ZTCConventional therapy + three-stage rehabilitation of strokeT: 0.15 ± 0.1 C: 0.14 ± 0.08①②③⑤⑥
Yonggang Wang 2017 [25]T: 74.7 ± 9.2 C: 73.1 ± 9.6112 (56/56)Conventional therapy + three-stage rehabilitation of stroke + ZTCConventional therapy + three-stage rehabilitation of strokeT: 8.9 ± 3.4 C: 9.3 ± 3.7②③⑤⑦
Peng Lei 2007 [26]T: 60.88 ± 9.03 C: 67.18 ± 35.6988 (66/22)Conventional therapy + ZTCConventional therapy + Naoan capsuleT: 1.2 ± 0.6 C: 1.3 ± 0.69①②④⑤
Qianfeng Ma 2015 [27]T: 61.2 ± 8.9 C: 63.4 ± 8.296 (48/48)Conventional therapy + atorvastatin + ZTCConventional therapy + atorvastatinT: 5.6 ± 1.8 C: 6.7 ± 1.9①②③

Note.: T—test group; C—control group. (1) Effective rate, (2) incidence of adverse reactions, (3) blood lipid level, (4) neurological deficit score, (5) TCM syndrome score, (6) modified Rankin scale score, and (7) hemorheology.