[Retracted] Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of “Chuanxiong Rhizoma: Radix Salviae miltiorrhizae” Herb Couples in the Treatment of Preeclampsia

Table 2

The detail of each pathway.

Pathway	Name	Description
hsa05167	Kaposi sarcoma-associated herpesvirus infection	It is the most recently identified human tumor virus and is associated with the pathogenesis of Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD).
hsa04380	Osteoclast differentiation	Osteoclastogenesis is mainly regulated by signaling pathways activated by rank and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from rank changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast.
hsa05418	Fluid shear stress and atherosclerosis	Sustained laminar flow with high shear stress upregulates expressions of endothelial cell (EC) genes and proteins that are protective against atherosclerosis.
hsa04657	IL-17 signaling pathway	The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses.
hsa04660	T-Cell receptor signaling pathway	Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28.
hsa04080	Neuroactive ligand receptor interaction	—
hsa05140	Leishmaniasis	Successful infection of Leishmania is achieved by alteration of signaling events in the host cell, leading to enhanced production of the autoinhibitory molecules like TGF-beta and decreased induction of cytokines such as IL12 for protective immunity.
hsa05162	Measles	The P, V, and C proteins act as virulence factors to suppress innate immune response in host by inhibiting signaling for both type I IFN induction and JAK/STAT-mediated interferon-stimulated gene (ISG) induction.
hsa05163	Human cytomegalovirus infection	HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3–K/AKT pathway.
hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	Upregulation of PD-L1 is caused by activation of pro-survival pathways MAPK and PI3K/Akt as well as transcriptional factors HIF-1, STAT3, and NF-kappa B.
hsa05161	Hepatitis B	After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA.
hsa04933	AGE-RAGE signaling pathway in diabetic complications	AGE/RAGE signaling elicits activation of multiple intracellular signal pathways involving NADPH oxidase, protein kinase C, and MAPKs, then resulting in NF-kappaB activity.
hsa04659	Th17 cell differentiation	Interleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell and neutrophil-mediated immune responses against extracellular microbes and in the pathogenesis of autoimmune diseases.
hsa04668	TNF signaling pathway	Tumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity.
hsa05145	Toxoplasmosis	During early infection, nuclear translocation of NFkB is temporally blocked and p38 MAPK phosphorylation is prevented, suppressing IL-12 production. Another pathway for IL-12 induction occurs through CCR5 dependent pathway, but parasitic induction of an eicosanoid LXA4 contributes to the downregulation of IL-12.
hsa04722	Neurotrophin signaling pathway	The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4).
hsa05135	Yersinia infection	Through inactivation of small GTPases by YopT protease, YopE GTPase-activating protein, and YpkA/YopO sequestration of GDP-bound small GTPases, Yersinia prevents its uptake by phagocytic cells and disrupts the actin cytoskeleton.
hsa04926	Relaxin signaling pathway	It belongs to the so-called relaxin peptide family which includes the insulin-like peptides INSL3 and INSL5, and relaxin-3 (H3) as well as relaxin.
hsa04917	Prolactin signaling pathway	PRL mediates its action through PRLR, a transmembrane protein of the hematopoietin cytokine receptor superfamily.
hsa04210	Apoptosis	Poptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases).