Mechanism Study of Cinnamomi Ramulus and <i>Paris polyphylla</i> Sm. Drug Pair in the Treatment of Adenomyosis by Network Pharmacology and Experimental Validation

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Gene</td><td class="align_center">Degreecentrality</td><td class="align_center">Betweennesscentrality</td><td class="align_center">Closenesscentrality</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">TP53</td><td class="align_center">18</td><td class="align_center">0.189524</td><td class="align_center">0.558442</td></tr><tr><td class="align_left">VEGFA</td><td class="align_center">17</td><td class="align_center">0.15469</td><td class="align_center">0.52439</td></tr><tr><td class="align_left">PTGS2</td><td class="align_center">13</td><td class="align_center">0.117131</td><td class="align_center">0.518072</td></tr><tr><td class="align_left">ESR1</td><td class="align_center">12</td><td class="align_center">0.086981</td><td class="align_center">0.477778</td></tr><tr><td class="align_left">PIK3CA</td><td class="align_center">9</td><td class="align_center">0.068537</td><td class="align_center">0.488636</td></tr><tr><td class="align_left">IL6</td><td class="align_center">15</td><td class="align_center">0.063904</td><td class="align_center">0.5375</td></tr><tr><td class="align_left">CXCL8</td><td class="align_center">12</td><td class="align_center">0.048844</td><td class="align_center">0.472527</td></tr><tr><td class="align_left">FGF2</td><td class="align_center">11</td><td class="align_center">0.046362</td><td class="align_center">0.43</td></tr><tr><td class="align_left">CCL2</td><td class="align_center">11</td><td class="align_center">0.036549</td><td class="align_center">0.457447</td></tr><tr><td class="align_left">IL10</td><td class="align_center">12</td><td class="align_center">0.031854</td><td class="align_center">0.467391</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Information of the 10 key targets.</div>

Evidence-Based Complementary and Alternative Medicine

tab2

Table 2

Table 2: Mechanism Study of Cinnamomi Ramulus and <i>Paris polyphylla</i> Sm. Drug Pair in the Treatment of Adenomyosis by Network Pharmacology and Experimental Validation 

Table 2 | Mechanism Study of Cinnamomi Ramulus and Paris polyphylla Sm. Drug Pair in the Treatment of Adenomyosis by Network Pharmacology and Experimental Validation 