Ethanol-Extracted Cameroonian Propolis Counteracts Tamoxifen-Induced Endometrial Hyperplasia by Modulating Apoptosis and Proliferation-Regulating Proteins in the Ovaries of Intact Wistar Rats

Figure 5

Photomicrographs (H&E staining, 400×) (a) and graphic representation (b) showing the effects of EECP on the vaginal epithelial height. NOR: rats treated with distilled water as normal control; Tamox: rats treated with tamoxifen only at the dose of 10 mg/kg BW as negative control; Ful: rats treated with the pure antiestrogen fulvestrant at the dose of 300 μg/kg BW as positive control; EECP: rats treated with the ethanol-extracted propolis from Cameroon at doses of 16.5, 50, and 150 mg/kg BW as test groups. All rats apart from those of the normal group (NOR) were concomitantly administered tamoxifen at the dose of 10 mg/kg BW for 8 weeks to induce endometrial hyperplasia. Significance compared to NOR group: ; significance compared to Tamox group: , , . Co: stratum corneum layer; Lu: vaginal lumen; Gr: stratum granulosa; Ge: stratum germinativum; St: stroma.

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