Ethanol-Extracted Cameroonian Propolis Counteracts Tamoxifen-Induced Endometrial Hyperplasia by Modulating Apoptosis and Proliferation-Regulating Proteins in the Ovaries of Intact Wistar Rats

Table 1

Effects of 56-day oral treatment with EECP on some protein levels expressed in the endometrium of the ovaries of intact rats exposed to tamoxifen.

	NOR	Tamox	Ful + Tamox	EECP (mg/kg) + Tamox
				16.5	50	150
Bcl-2	12.14 ± 1.3	16.56 ± 1.77^#	14.25 ± 0.69	16.42 ± 0.87^#	13.54 ± 0.74	12.88 ± 1.52
Bax	19.07 ± 1.9	14.73 ± 1.07^#	21.60 ± 2.04	13.88 ± 1.29	15.57 ± 1.13	17.98 ± 1.16
VEGF	11.22 ± 0.9	14.54 ± 0.58^#	15.10 ± 0.63	16.67 ± 0.78	11.34 ± 1.27	10.85 ± 1.07
Caspase-3	13.5 ± 0.72	14.52 ± 1.36	13.73 ± 1.78	14.01 ± 0.69	16.48 ± 0.91	18.42 ± 0.73
PCNA	7.12 ± 0.72	10.11 ± 0.94^#	6.07 ± 1.06	10.62 ± 1.46^#	7.75 ± 0.94	7.04 ± 0.55

NOR: rats treated with distilled water as normal control; Tamox: rats treated with tamoxifen only at the dose of 10 mg/kg BW as negative control; Ful: rats treated with the pure antiestrogen fulvestrant at the dose of 300 μg/kg BW as positive control; EECP: rats treated with the ethanol-extracted propolis from Cameroon at doses of 16.5, 50, and 150 mg/kg BW as test groups. All rats apart from those of the normal group (NOR) were concomitantly administered tamoxifen at the dose of 10 mg/kg BW for 8 weeks to induce endometrial hyperplasia. Significance compared to NOR group: ; significance compared to Tamox group: , , .