Ethanol-Extracted Cameroonian Propolis Counteracts Tamoxifen-Induced Endometrial Hyperplasia by Modulating Apoptosis and Proliferation-Regulating Proteins in the Ovaries of Intact Wistar Rats
Table 3
Effects of ethanol-extracted Cameroonian propolis on some organ wet weights of rats exposed to tamoxifen.
Organs
NOR
Tamox
Ful + Tamox
Propolis (mg/kg) + Tamox
16.5
50
150
Liver
35154.35 ± 2443.31
31629.69 ± 1743.96
31775.94 ± 1356.68
34465.65 ± 1600.66
31308.05 ± 3110.49
29960.88 ± 1274.52
Lungs
8049.97 ± 218.69
8242.59 ± 297.05
8055.40 ± 420.15
8662.95 ± 676.63
6931.63 ± 398.52
6948.66 ± 353.29
Spleen
3640.16 ± 260.89
2845.29 ± 190.55
3460.98 ± 479.86
3535.42 ± 363.46
3496.95 ± 368.61
2929.93 ± 171.96
Adrenals
359.91 ± 42.09
373.98 ± 26.03
289.38 ± 9.38
365.07 ± 19.85
337.28 ± 28.48
316.70 ± 16.44
Kidneys
6232.45 ± 495.42
6769.13 ± 429.19
6666.26 ± 274.20
7555.93 ± 486.37
6626.18 ± 340.74
6609.92 ± 353.80
Femur
2784.48 ± 244.97
2974.92 ± 107.33
2404.77 ± 86.05
2725.13 ± 225.16
2557.32 ± 178.13
2731.94 ± 135.08
Brain
7549.21 ± 472.69
9140.60 ± 348.10#
8092.52 ± 354.54
8567.41 ± 510.52
8592.23 ± 427.23
8586.46 ± 309.92
Ovaries
526.11 ± 42.87
387.79 ± 22.73
381.40 ± 63.82
404.61 ± 48.35
468.00 ± 58.30
361.06 ± 53.91
Stomach
9437.52 ± 613.18
9609.25 ± 753.10
9453.80 ± 301.13
9300.52 ± 449.56
9251.86 ± 439.42
9322.35 ± 443.84
Heart
2965.42 ± 306.94
3572.65 ± 232.78
3810.40 ± 118.33
3869.70 ± 234.81
3762.17 ± 234.81
3508.87 ± 74.18
NOR: rats treated with distilled water as normal control; Tamox: rats treated with tamoxifen only at the dose of 10 mg/kg BW as negative control; Ful: rats treated with the pure antiestrogen fulvestrant at the dose of 300 μg/kg BW as positive control; EECP: rats treated with the ethanol-extracted propolis from Cameroon at doses of 16.5, 50, and 150 mg/kg BW as test groups. All rats apart from those of the normal group (NOR) were concomitantly administered tamoxifen at the dose of 10 mg/kg BW for 8 weeks to induce endometrial hyperplasia. Significance compared to NOR group: .
