Oxymatrine Protects Chondrocytes against IL-1<i>β</i>-triggered Apoptosis <i>in Vitro</i> and Inhibits Osteoarthritis in Mice Model

<div>TUNEL and IHC staining for BCL-2 and Bax show the effect of OMT on progression of ACLT-triggered OA mice. (a) TUNEL results of mice in each group 8 weeks following surgery. Scale bar: 100 <i>μ</i>m. Right: results of statistical analyses of apoptotic chondrocyte rate. (b) IHC staining for BCL-2 and Bax expression of mice in each group 8 weeks following surgery. Scale bar: 100 <i>μ</i>m. 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transform="matrix(.013,0,0,-0.013,38.365,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"></path></g></svg> and <sup>###</sup><svg height="9.2729pt" id="M21" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 51.1027 9.2729" width="51.1027pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 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602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,44.605,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> vs sham group.</div>

Evidence-Based Complementary and Alternative Medicine

fig6

Figure 6

Figure 6: Oxymatrine Protects Chondrocytes against IL-1<i>β</i>-triggered Apoptosis <i>in Vitro</i> and Inhibits Osteoarthritis in Mice Model 

Evidence-Based Complementary and Alternative Medicine

Oxymatrine Protects Chondrocytes against IL-1β-triggered Apoptosis in Vitro and Inhibits Osteoarthritis in Mice Model

Figure 6